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apalutamide will minimize the extent or impact of modafinil by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. Coadministration of apalutamide, a strong CYP3A4 inducer, with medicine which are CYP3A4 substrates can lead to decrease publicity to these drugs.posaconazole will boost the level or result of modafini